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An open-label investigator research grant trial to establish the safety of intravitreous injections of E10030 (anti-PDGF pegylated aptamer) given in combination with Lucentis® in subjects with neovascular age-related macular degeneration




The objectives of this study are to evaluate the safety and efficacy of E10030 intravitreous injection when administered in combination with Lucentis® against a control of Lucentis® alone in subjects with subfoveal choroidal neovascularization secondary to age-related macular degeneration (AMD) in poor-responders to anti-VEGF monotherapy.

RESULTS: Patients who were previously poor-responders to Lucentis® monotherapy, after receiving the combination of Fovista (1.5 mg) and Lucentis®, gained a mean of 6.1 letters of vision on the ETDRS standardized chart at 12 weeks. Some patients showed marked lesion reduction. No significant safety issues were observed. Data under analysis pending publication.

Интравитреальные инъекцииВМД атрофическая или сухая.Экссудативная или влажная ВМДАнгиография с индоцианином зеленымАвтофлюоресценцияМикропериметрияФлюоресцентная ангиографияТомография оптической когерентности


Доктор Jordi Monés, M.D., Ph.D.
Номер лицензии COMB: 22.838
Доктор Медицины и Хирургии
Специалист по Офтальмологии
Специалист по лечению Сетчатки, Макулы и Стекловидного тела

Last modified: 2 July, 2020 - 11:57