Publications
The research vocation of the Institut de la Màcula and all its members leads us to collaborate in global investigations that are featured in renowned publications worldwide. Below are some of the scientific articles in which our researchers have participated in recent years.
- Wu, Z., Sadda, S. R., Ach, T., Blodi, B. A., Bottoni, F., Chakravarthy, U., Chew, E. Y., Curcio, C. A., Ferris, F. L., 3rd, Fleckenstein, M., Freund, K. B., Grunwald, J. E., Holz, F. G., Jaffe, G. J., Liakopoulos, S., Lim, T. H., Monés, J. M., Pagliarini, S., Pauleikhoff, D., Pfau, M., … Guymer, R. H. (2025). Onset of End-Stage Atrophic Age-Related Macular Degeneration as an End Point-A Delphi Study: Classification of Atrophy Meetings Report 7. Ophthalmology science, 5(5), 100777. https://doi.org/10.1016/j.xops.2025.100777. Set. 2025.
- Gurudas S, Marques I, Girmens JF, Lechanteur Y, Parravano MC, Berger L, Agostini H, Barrão S, Tsiroukis E, Monés J, Sararols L, Silva R, Scholl H, Lommatzsch A, Stanzel B, Vujosevic S, Sivaprasad S; INTERCEPT-AMD Study Group. Visual acuity in various phenotypes of intermediate age related macular degeneration (AMD) in a multicentre cohort study in Europe- INTERCEPT-AMD report 1. Eye (Lond). 2025 Jul 19. doi: 10.1038/s41433-025-03895-y. Epub ahead of print. PMID: 40684053. Jul. 2025.
- Wykoff, C. C., Holz, F. G., Chiang, A., Boyer, D., Dhoot, D. S., Loewenstein, A., Mones, J., Heier, J., Abbey, A. M., Singerman, L. J., Vajzovic, L., Lin, J., Li, C., Vilupuru, A., Baumal, C. R., & OAKS, DERBY, and GALE Investigators (2025). Pegcetacoplan Treatment for Geographic Atrophy in Age-Related Macular Degeneration Over 36 Months: Data From OAKS, DERBY, and GALE. American journal of ophthalmology, 276, 350–364. https://doi.org/10.1016/j.ajo.2025.04.016. Abr. 2025.
- Monés J, Pagani F, Santmaría JF, Garcia M, Romero C, Garcia D, Serrano A, Carrasco A. Spontaneous Soft Drusen Regression without Atrophy and the Drusen Ooze. Ophthalmol Retina. 2025 Feb 28:S2468-6530(25)00093-4. doi: 10.1016/j.oret.2025.02.023. Epub ahead of print. PMID: 40024370. Feb. 2025.
- Santamaría J, Pagani F, Monés J. Complete retinal pigment epithelium and outer retinal atrophy: Is it really an end-stage atrophy? Eur J Ophthalmol. 2025 Jan;35(1):NP41-NP45. doi: 10.1177/11206721241290263. Epub 2024 Oct 15. PMID: 39410789. Oct. 2024.
- Agostini, H., Abreu, F., Baumal, C. R., Chang, D. S., G Csaky, K., Demetriades, A. M., Kodjikian, L., Lim, J. I., Margaron, P., Monés, J. M., Peto, T., Ricci, F., Rüth, M., Singh, R. P., Stoilov, I., Swaminathan, B., Willis, J. R., & Westenskow, P. D. (2024). Faricimab for neovascular age-related macular degeneration and diabetic macular edema: from preclinical studies to phase 3 outcomes. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 262(11), 3437–3451. https://doi.org/10.1007/s00417-024-06531-9. Jun. 2024.
- Heier JS, Lad EM, Holz FG, Rosenfeld PJ, Guymer RH, Boyer D, Grossi F, Baumal CR, Korobelnik JF, Slakter JS, Waheed NK, Metlapally R, Pearce I, Steinle N, Francone AA, Hu A, Lally DR, Deschatelets P, Francois C, Bliss C, Staurenghi G, Monés J, Singh RP, Ribeiro R, Wykoff CC; OAKS and DERBY study investigators. Pegcetacoplan for the treatment of geographic atrophy secondary to age-related macular degeneration (OAKS and DERBY): two multicentre, randomised, double-masked, sham-controlled, phase 3 trials. Lancet. 2023 Oct 21;402(10411):1434-1448. doi: 10.1016/S0140-6736(23)01520-9. PMID: 37865470. Oct. 2023.
- Khanani AM, Patel SS, Staurenghi G, Tadayoni R, Danzig CJ, Eichenbaum DA, Hsu J, Wykoff CC, Heier JS, Lally DR, Monés J, Nielsen JS, Sheth VS, Kaiser PK, Clark J, Zhu L, Patel H, Tang J, Desai D, Jaffe GJ; GATHER2 trial investigators. Efficacy and safety of avacincaptad pegol in patients with geographic atrophy (GATHER2): 12-month results from a randomised, double-masked, phase 3 trial. Lancet. 2023 Oct 21;402(10411):1449-1458. doi: 10.1016/S0140-6736(23)01583-0. Epub 2023 Sep 8. PMID: 37696275.. Oct. 2023.
- Biarnés M, Ferraro LL, Hernán I, Gamundi MJ, Garcia Planas M, Abadías C, Romero C, Carrasco A, Carballo M, Monés J. “Night blindness and hearing loss associated with choroideremia.” Clinical & experimental optometry, 1-4. 22 Jun. 2023.
- Ogura Y, Jaffe GJ, Cheung CMG, Kokame GT, Iida T, Takahashi K, Lee WK, Chang AA, Monés J, D'Souza D, Weissgerber G, Gedif K, Koh A. “Efficacy and safety of brolucizumab versus aflibercept in eyes with polypoidal choroidal vasculopathy in Japanese participants of HAWK.” The British journal of ophthalmology vol. 106,7 (2022): 994-999.
- Monés, Jordi. “A 10-point score classification for anti-VEGF response in exudative AMD.” Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie vol. 260,6 (2022): 2073-2074.
- Rodríguez-Bocanegra E, Biarnés M, Garcia M, Ferraro LL, Fischer MD, Monés J. “Kinetics of Heterogeneous Background in Stargardt's Disease over Time.” Life (Basel, Switzerland) vol. 12,3 381. 6 Mar. 2022.
- de Breuk A, Acar IE, Kersten E, Schijvenaars MMVAP, Colijn JM, Haer-Wigman L, Bakker B, de Jong S, Meester-Smoor MA, Verzijden T, Missotten TOAR, Monés J, Biarnés M, Pauleikhoff D, Hense HW, Silva R, Nunes S, Melo JB, Fauser S, Hoyng CB, Ueffing M, Coenen MJH, Klaver CCW, den Hollander AI; EYE-RISK Consortium. “Development of a Genotype Assay for Age-Related Macular Degeneration: The EYE-RISK Consortium.” Ophthalmology vol. 128,11 (2021): 1604-1617.
- Biarnés, Marc et al. “Re: Keenan et al.: Cluster Analysis and Genotype-Phenotype Assessment of Geographic Atrophy in Age-Related Macular Degeneration: AREDS2 Report 25 (Ophthalmology. 2021;5(11):1061-1073).” Ophthalmology. Retina vol. 6,4 (2022): 333-334.
- Colijn, Johanna M et al. “Enlargement of Geographic Atrophy From First Diagnosis to End of Life.” JAMA ophthalmology vol. 139,7 (2021): 743-750.
- Monés, Jordi et al. “ASYMETRIC GROWTH OF MACULAR ATROPHY ASSOCIATED WITH UNDERLYING MATURE, NONEXUDATIVE CHOROIDAL NEOVASCULARIZATION.” Retinal cases & brief reports vol. 15,6 (2021): 778-782.
- Jaffe, Glenn J et al. “Imaging Features Associated with Progression to Geographic Atrophy in Age-Related Macular Degeneration: Classification of Atrophy Meeting Report 5.” Ophthalmology. Retina vol. 5,9 (2021): 855-867.
- Pazos, Marta et al. “SD-OCT peripapillary nerve fibre layer and ganglion cell complex parameters in glaucoma: principal component analysis.” The British journal of ophthalmology vol. 105,4 (2021): 496-501.
- Duarri, Anna et al. “Transplantation of Human Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium in a Swine Model of Geographic Atrophy.” International journal of molecular sciences vol. 22,19 10497. 28 Sep. 2021.
- Steinle, Nathan C et al. “Impact of Baseline Characteristics on Geographic Atrophy Progression in the FILLY Trial Evaluating the Complement C3 Inhibitor Pegcetacoplan.” American journal of ophthalmology vol. 227 (2021): 116-124.
- Biarnés, Marc et al. “Genotype- and Phenotype-Based Subgroups in Geographic Atrophy Secondary to Age-Related Macular Degeneration: The EYE-RISK Consortium.” Ophthalmology. Retina vol. 4,12 (2020): 1129-1137.
- Jaffe, Glenn J et al. “C5 Inhibitor Avacincaptad Pegol for Geographic Atrophy Due to Age-Related Macular Degeneration: A Randomized Pivotal Phase 2/3 Trial.” Ophthalmology vol. 128,4 (2021): 576-586.
- Monés, Jordi et al. “Risk of Inflammation, Retinal Vasculitis, and Retinal Occlusion-Related Events with Brolucizumab: Post Hoc Review of HAWK and HARRIER.” Ophthalmology vol. 128,7 (2021): 1050-1059. doi:10.1016/j.ophtha.2020.11.011.
- Spaide, Richard F et al. “Consensus Nomenclature for Reporting Neovascular Age-Related Macular Degeneration Data: Consensus on Neovascular Age-Related Macular Degeneration Nomenclature Study Group.” Ophthalmology vol. 127,5 (2020): 616-636.
- Rodríguez, Anabel et al. “Early Detection of Incipient Retinal Pigment Epithelium Atrophy Overlying Drusen with Fundus Autofluorescence vs. Spectral Domain Optical Coherence Tomography.” Journal of ophthalmology vol. 2020 9457457. 16 Sep. 2020.
- Holekamp, Nancy et al. “Natural History of Geographic Atrophy Secondary to Age-Related Macular Degeneration: Results from the Prospective Proxima A and B Clinical Trials.” Ophthalmology vol. 127,6 (2020): 769-783.
- Sadda, SriniVas R et al. “Anti-Vascular Endothelial Growth Factor Use and Atrophy in Neovascular Age-Related Macular Degeneration: Systematic Literature Review and Expert Opinion.” Ophthalmology vol. 127,5 (2020): 648-659.
- Guymer, Robyn H et al. “Incomplete Retinal Pigment Epithelial and Outer Retinal Atrophy in Age-Related Macular Degeneration: Classification of Atrophy Meeting Report 4.” Ophthalmology vol. 127,3 (2020): 394-409.
- Monés, Jordi et al. “Undertreatment of Neovascular Age-Related Macular Degeneration after 10 Years of Anti-Vascular Endothelial Growth Factor Therapy in the Real World: The Need for A Change of Mindset.” Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde vol. 243,1 (2020): 1-8.
- Biarnés, Marc, and Jordi Monés. “Regression to the Mean in Measurements of Growth Rates in Geographic Atrophy.” Ophthalmic research vol. 63,5 (2020): 460-465.
- Ramon, Clara et al. “Longitudinal changes in outer nuclear layer thickness in soft drusen and reticular pseudodrusen.” Clinical & experimental optometry vol. 102,6 (2019): 601-610.
- Monés, Jordi, and Marc Biarnés. “Geographic atrophy phenotype identification by cluster analysis.” The British journal of ophthalmology vol. 102,3 (2018): 388-392.
- Sadda, Srinivas R et al. “Consensus Definition for Atrophy Associated with Age-Related Macular Degeneration on OCT: Classification of Atrophy Report 3.” Ophthalmology vol. 125,4 (2018): 537-548. doi:10.1016/j.ophtha.2017.09.028
- Monés, Jordi et al. “Intravitreal aflibercept efficacy in neovascular age-related macular degeneration with suboptimal response to anti-vascular endothelial growth factor-A therapy.” European journal of ophthalmology vol. 30,5 (2020): 1082-1090.
- Larsen, Michael et al. “Sustained Benefits from Ranibizumab for Central Retinal Vein Occlusion with Macular Edema: 24-Month Results of the CRYSTAL Study.” Ophthalmology. Retina vol. 2,2 (2018): 134-142.
- Badal, Josep et al. “Performance characteristics of multicolor versus blue light and infrared imaging in the identification of reticular pseudodrusen.” International ophthalmology vol. 38,1 (2018): 199-206.
- Monés, Jordi et al. “Drusen Ooze: A Novel Hypothesis in Geographic Atrophy.” Ophthalmology. Retina vol. 1,6 (2017): 461-473.
- Jaffe, Glenn J et al. “Dual Antagonism of PDGF and VEGF in Neovascular Age-Related Macular Degeneration: A Phase IIb, Multicenter, Randomized Controlled Trial.” Ophthalmology vol. 124,2 (2017): 224-234.
- Holz, Frank G et al. “Imaging Protocols in Clinical Studies in Advanced Age-Related Macular Degeneration: Recommendations from Classification of Atrophy Consensus Meetings.” Ophthalmology vol. 124,4 (2017): 464-478.
- Silva, Rufino et al. “Treat-and-Extend versus Monthly Regimen in Neovascular Age-Related Macular Degeneration: Results with Ranibizumab from the TREND Study.” Ophthalmology vol. 125,1 (2018): 57-65.
- Monés, Jordi et al. “A Swine Model of Selective Geographic Atrophy of Outer Retinal Layers Mimicking Atrophic AMD: A Phase I Escalating Dose of Subretinal Sodium Iodate.” Investigative ophthalmology & visual science vol. 57,10 (2016): 3974-83.
- Monés, Jordi et al. “FEEDER VESSEL LASER PHOTOCOAGULATION FOR IDIOPATHIC, SUBFOVEAL POLYPOIDAL CHOROIDAL VASCULOPATHY NOT RESPONDING TO EITHER ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY OR PHOTODYNAMIC THERAPY.” Retinal cases & brief reports vol. 10,1 (2016): 100-3.
- Tadayoni, Ramin et al. “Individualized Stabilization Criteria-Driven Ranibizumab versus Laser in Branch Retinal Vein Occlusion: Six-Month Results of BRIGHTER.” Ophthalmology vol. 123,6 (2016): 1332-44.
- Larsen, Michael et al. “Individualized Ranibizumab Regimen Driven by Stabilization Criteria for Central Retinal Vein Occlusion: Twelve-Month Results of the CRYSTAL Study.” Ophthalmology vol. 123,5 (2016): 1101-11.
- Biarnés, Marc et al. “Increased Fundus Autofluorescence and Progression of Geographic Atrophy Secondary to Age-Related Macular Degeneration: The GAIN Study.” American journal of ophthalmology vol. 160,2 (2015): 345-353.e5.
- Richard, Gisbert et al. “Scheduled versus Pro Re Nata Dosing in the VIEW Trials.” Ophthalmology vol. 122,12 (2015): 2497-503.
- Gerding, Heinrich et al. “Ranibizumab in retinal vein occlusion: treatment recommendations by an expert panel.” The British journal of ophthalmology vol. 99,3 (2015): 297-304.
- Biarnés, Marc et al. “Reappraisal of geographic atrophy patterns seen on fundus autofluorescence using a latent class analysis approach.” Investigative ophthalmology & visual science vol. 55,12 8302-8. 18 Nov. 2014.
- Monés, Jordi et al. “Bimonthly half-dose ranibizumab in large pigment epithelial detachment and retinal angiomatous proliferation with high risk of retinal pigment epithelium tear: a case report.” Clinical ophthalmology (Auckland, N.Z.) vol. 7 (2013): 1089-92.
- Monés, Jordi et al. “Hyporeflective wedge-shaped band in geographic atrophy secondary to age-related macular degeneration: an underreported finding.” Ophthalmology vol. 119,7 (2012): 1412-9.